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Personalized skin cancer vaccine reduces risk of recurrence or death

Phase 3 clinical trial indicates that mRNA-based therapy combined with immunotherapy decreased the relative risk of disease return or death by 42%, but the treatment remains investigational.

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The essentials of this story

What happened
A therapeutic vaccine combined with immunotherapy reduced the relative risk of melanoma recurrence or death by 42% in a phase 3 study.
Who is affected
Patients with cutaneous melanoma in stages IIB to IV who underwent surgical tumor removal.
What changes
Personalized mRNA therapy combined with Keytruda demonstrates superior efficacy against tumor recurrence compared to the isolated use of the drug, although the treatment remains investigational and without regulatory approval.

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Sources

  1. Entenda como funciona a nova vacina “personalizada” contra câncer de pele — CNN Brasil (accessed 10/23/2026)