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Lung cancer: study shows 7-year disease control with lorlatinib

Patients who completed two years of treatment without tumor progression have a 79% probability of remaining stable through the seventh year, according to updated data from the CROWN clinical trial.

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The essentials of this story

What happened
Phase 3 clinical trial demonstrates prolonged efficacy of medication for ALK-mutated lung cancer.
Who is affected
Patients with advanced, ALK-positive non-small cell lung cancer.
What changes
Treatment with lorlatinib keeps the disease under control for seven years in more than half of the patients, surpassing the results of previous therapies.

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Sources

  1. Câncer de pulmão: comprimido diário mantém doença avançada controlada por 7 anos — Olhar Digital (accessed 11/01/2026)
  2. Remédio para câncer de pulmão pode evitar avanço da doença por 7 anos — CNN Brasil (accessed 11/01/2026)